AKTIP anticorps (Middle Region)

N° du produit ABIN1449900

Cet anticorps anti-AKTIP est un anticorps Lapin Polyclonal détectant AKTIP dans WB. Adapté pour Humain, Souris, Rat, Chien, Poisson zèbre (Danio rerio), Poulet et Xenopus laevis.

Aperçu rapide pour AKTIP anticorps (Middle Region) (ABIN1449900)

Antigène: AKTIP (AKT Interacting Protein (AKTIP))

Reactivité: Humain, Souris, Rat, Chien, Poisson zèbre (Danio rerio), Poulet, Xenopus laevis

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp AKTIP est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-AKTIP anticorps

Épitope: Middle Region

Séquence: NPSVHDEARE KMLTQKKPEE QHNKSVHVAG LSWVKPGSVQ PFSKEEKTVA

Réactivité croisée (Details): Species reactivity (expected):Mouse, Rat, Chicken, Dog, African clawed frog, ZebrafishSpecies reactivity (tested):Human

Purification: Purified using peptide immunoaffinity column

Immunogène: Synthetic peptide directed towards the middle region of human AKTIP

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Reconstitution: Add 50 μL of distilled water to a final concentration of 1 mg/mL.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store lyophilized at 2-8 °C or at -20 °C long term. After reconstitution store the antibody undiluted at 2-8 °C for up to one month or in aliquots at -20 °C long term.

Détails sur AKTIP

Antigène: AKTIP (AKT Interacting Protein (AKTIP))

Autre désignation: AKTIP / FTS

Sujet: AKTIP is the component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). AKTIP regulates apoptosis by enhancing phosphorylation and activation of AKT1. AKTIP increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade.The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.Synonyms: AKT-interacting protein, FT1, Fused toes protein homolog

ID gène: 64400

NCBI Accession: NP_001012398